Northumbria Police is appealing for witnesses or dash-cam footage following a three-vehicle collision on the A196 between Morpeth and Guide Post on Wednesday.
The collision involved a white gold Volkswagen, a black Seat Ibiza and a red Fiat 500 and a passenger in one of the cars was seriously injured.
The force received a report of the incident at about 5.30pm.
Emergency services attended and the road was closed whilst they worked.
A Northumbria Police spokeswoman said: “A passenger in the Fiat 500, a 50-year-old woman, was taken to hospital with serious injuries.
“Anyone with any information or dash-cam footage is asked to get in touch with police via 101 – quote reference number 813 12/12/18.